Dr. Mehdi Sadeghi, born on December 20, 1963 in Garmsar, Iran, is a distinguished Iranian scientist in the fields of biophysics, bioinformatics, and computational biology. Although he was born in Garmsar, he is of Mazandarani and Firuzkuhi origin. He currently serves as an Professor and faculty member at the National Institute of Genetic Engineering and Biotechnology (NIGEB).

1. Early Life and Education

Dr. Sadeghi pursued all of his higher education at the University of Tehran, one of Iran’s most prestigious academic institutions. His academic career reflects exceptional distinction and excellence.

• Ph.D. in BiophysicsCenter for Biochemistry and Biophysics, University of Tehran
• M.Sc. in BiophysicsCenter for Biochemistry and Biophysics, University of Tehran
• B.Sc. in Cellular and Molecular BiologyFaculty of Science, University of Tehran

He graduated with first rank in both his undergraduate and master’s studies.

2. Academic and Professional Activities

Dr. Sadeghi is regarded as one of the important figures in the development and promotion of bioinformatics in Iran. His scientific and academic activities span research, teaching, supervision, and professional service.

Teaching

He has taught a wide range of specialized courses at the graduate level, including:

• Bioinformatics
• Protein Engineering
• Structure of Macromolecules
• Molecular Biology

He has offered these courses in several major Iranian institutions, including:

• University of Tehran
• Tarbiat Modares University
• National Institute of Genetic Engineering and Biotechnology
• Imam Hossein University
• Islamic Azad University

Scientific and Professional Service

Dr. Sadeghi has played an active role in scientific societies and specialized committees, including:

• Board Member, Iranian Bioinformatics Society
• Board Member, Iranian Proteomics Society
• Member, Clinical Proteomics Committee of the Academy of Medical Sciences
• Head of the Bioinformatics Committee, Iranian Biological Society
• Member, Bioinformatics Group, Center for Biochemistry and Biophysics, University of Tehran
• Member, Molecular Commission of the Biotechnology Group
• Head of the Bioinformatics Core, Institute for Studies in Theoretical Physics and Mathematics

3. Research Contributions and Publications

Dr. Sadeghi has an extensive and influential research record, with more than 65 international journal articles published in reputable scientific journals such as:

• BMC Bioinformatics
• Journal of Theoretical Biology
• Proteins
• Mathematical Biosciences
• Computational Biology and Chemistry
• Biophysical Chemistry

Main Research Areas

His research has focused on several major areas, including:

• Prediction of protein secondary and tertiary structure
• Protein fold recognition
• Haplotype inference and genomic data analysis
• Motif discovery in DNA and RNA sequences
• Protein interaction networks
• Computational modeling in molecular biology
• Thermostability of proteins, especially thermophilic proteins
• Applications of graph theory, hidden Markov models, dynamic programming, and machine learning in bioinformatics

Books and Persian Publications

In addition to his international publications, Dr. Sadeghi has contributed to scholarly works in Persian. Among them is his co-authorship of a chapter in the book:

• “Thermal Stability of Proteins and Its Application in Biotechnology”Chapter 7 of Physical Chemistry of Biological Macromolecules, University of Tehran Press

He has also authored Persian scientific and interdisciplinary works, including articles on gene synthesis, catalytic RNA, catalytic antibodies, and even the use of computers in Persian literary chronograms.

4. Thesis Supervision and Academic Mentorship

Dr. Sadeghi has supervised or advised more than 40 master’s and doctoral theses across a wide range of interdisciplinary topics connecting biology, mathematics, computer science, and biotechnology.

His students’ research topics have included:

• Protein structure prediction
• Haplotype reconstruction
• SNP selection
• Alternative splicing prediction
• Graph-theoretical analysis of protein structures
• Motif finding in biological sequences
• Protein interaction modeling
• Computational genomics

Through this sustained mentorship, he has played an important role in training a generation of researchers in bioinformatics and computational biology in Iran.

5. Awards and Honors

Dr. Sadeghi’s academic and scientific achievements have been recognized through several honors, including:

• Outstanding Researcher of the Year (2010)National Institute of Genetic Engineering and Biotechnology
• First Rank in B.Sc. studies, University of Tehran
• First Rank in M.Sc. studies, University of Tehran

6. Summary

Dr. Mehdi Sadeghi is a prominent Iranian scholar whose work has significantly contributed to the advancement of bioinformatics, biophysics, and computational molecular biology in Iran. Through his research, teaching, professional leadership, and supervision of graduate students, he has helped shape the scientific foundations of modern bioinformatics in the country.

His career reflects a rare combination of deep theoretical knowledge, interdisciplinary research strength, and long-standing academic service.